(Versed)

Class:

Sedative and Hypnotic

Description:

Midazolam is a benzodiazepine with strong hypnotic and amnestic properties.

Mechanism of Action:

Midazolam is a potent but short-acting benzodiazepine used as a sedative and hypnotic. It is three to four times more potent than Diazepam. Its onset of action is approximately 1.5 minutes when administered IV. Midazolam has impressive amnestic properties, and like other benzodiazepines, it has no effect on pain.

Indications:

Midazolam is used as a premedication before cardioversion and other painful procedures.

Contraindications:

Known hypersensitivity, narrow angle glaucoma, shock, depressed vital signs, and alcoholic coma.

Precautions:

Emergency resuscitative equipment must be available prior to the administration of Midazolam. Midazolam has more potential than the other benzodiazepines to cause respiratory depression and respiratory arrest.

Side Effects:

Laryngospasm, bronchospasm, dyspnea, respiratory depression and arrest, drowsiness, altered mental status, amnesia, bradycardia, tachycardia, premature ventricular contractions, and retching.

Interactions:

The effects of Midazolam can be accentuated by CNS depressants such as narcotics and alcohol.

Dosage and administration

• Adults:
  • For sedation – 2.0-2.5 mg slow IV over 2-3 minutes. May be repeated to max of 0.1mg/kg
• Peds: Not recommended