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Pharmacology II – RSI
January 7th, 2009 by RH-111
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1/7/09 (UPDATED 1/11/08

RSI (Rapid sequence intubation)

Indications:

  • Trauma with GCS of <9, with gag reflex or significant facial trauma
  • Closed head injury – major stroke
  • Burn patients
  • Any patient who can’t maintain an airway, still has gag reflex,- with possibility of successful intubation

6 ps

  • Prep
  • Preoxygenate, sat at 100% (do not bag while patient is under, all sphincters are relaxed)
  • Pretreat (medicating)
    • LOAD
      • Lidocaine – 1-1.5 mg/kg (suppress gag reflex – gag can increase ICP)
      • (Opiods – Fentanyl 3mcg/kg IV – decrease sympathetic response – also for AA or ICP)
      • Atropine –0.02 mg/kg – decreases parasympathetic response (also decreases brady affect of Succinylcholine- especially peds)
      • (Defasiculating dose – 10% of normal dose (non-depolarizing) – 2-5 minutes before Succinylcholine)(
        Vecuronium 0.1mg/kg) -

         

  • Induction (sedation)
    • Etomidate – 0.3 mg/kg
      • Rapid onset – 15-45 sec
      • Short duration – 3-12 min
    • Midazolam (Versed) – 0.1-0.3 mg/kg – usual dose is 2 mg because causes hypotension
      • 30-60 sec onset
      • 15-30 minute duration
      • Amnesic effects
  • Paralysis (not performed in NYS by paramedics)
    • Bind to ACH nicotinic receptors
    • Depolarizing
      • Succinylcholine (sux) – binds to Ach receptors blocking contraction of muscle
      • 1-2mg/kg – max 150mg
      • Peds 1-1.5mg/kg
        • Hyperkalemia (renal problems, significant muscle damage, burn patients, )
        • Bradycardia
        • Dysrythmias
        • hypertension
    • Non-depolarizing
      • Do not cause fasciculations
      • Longer onset
      • Longer action
    • Paralyzed patient has no definitive airway
    • Must be ventilated manually throughout duration of paralysis
    • No affect on mental status – MUST sedate
  • Placement of tube
  • Post intubation management


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